- Chosen by Empire magazine as one of the "100 Sexiest Stars in Film History" (#46). 
- Has Adult Onset Asthma.
- Born at 2:49am PST.
- Has never married.
- Adopted a baby girl in January 1996.
- She is left handed.
- She is not related to Michael Keaton. Diane Keaton (birthname Diane Hall) changed her last name to her mother's maiden name as a result of a Diane Hall already being in the actors' guild. According to her, Michael Keaton had a similar problem with his natural name when entering the actors' guild, though he picked "Keaton" because he liked Diane's name. - Diane Keaton, "Oprah" 2/4/2000
- Adopted a baby boy in 2001. Children are named Dexter and Duke.
- Was part of the original cast of the Broadway musical "Hair" (1968).
- Woody Allen said of her, "In real life, Keaton believes in God. But she also believes that the radio works because there are tiny people inside it."
- She wanted to direct a remake of the film Blaue Engel, Der (1930) (aka "The Blue Angel") with Madonna in the lead but the project was canceled.
- Was nominated for Broadway's 1969 Tony Award as Best Supporting or Featured Actress (Dramatic) for "Play It Again, Sam," a performance she recreated in the film version with the same title, Play It Again, Sam (1972).
- In both her 1977 films, "Annie Hall" and "Looking for Mr. Goodbar", "The Godfather" is referenced. In "Annie Hall", Woody Allen mentions the film as two men bother him for an autograph outside a movie theater and in "Goodbar", Theresa (Keaton) is seen reading Mario Puzo's "The Godfather" at a bar counter when Richard Gere approaches her.
- Two of her four Oscar-nominated roles were directed by her then boyfriends: Annie Hall (1977) (which won her an Oscar) was directed by Woody Allen and Reds (1981) was directed by Warren Beatty
- She and Woody Allen made 8 movies together: Annie Hall (1977), Love and Death (1975), Manhattan (1979), Manhattan Murder Mystery (1993), Radio Days (1987), Play It Again, Sam (1972), Interiors (1978) and Sleeper (1973)
- Created a new fashion style in the 70s, when women all over the world started to copy her style of wearing suits and ties, which first got recognized by the public in Annie Hall (1977).
- Starred in a film called Annie Hall (1977). Her real name is Diane Hall and her nickname is Annie.
- Her performance as Annie Hall in Annie Hall (1977) is ranked #60 on Premiere Magazine's 100 Greatest Performances of All Time (2006).
- Her performance as Annie Hall in "Annie Hall" (1977) is ranked $6 on Premiere Magazine's 100 Greatest Movie Characters of All Time.
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