- Sister of Elisabeth Huppert.
- She was present at the Stade De France in 1998 with her son to see France win the Football World Cup.
- The youngest of the five children. 3 sisters and 1 brother, including director Caroline Huppert and actress/writer/director Elisabeth Huppert.
- 3 children: Lolita (b. October 1983), Lorenzo (b. 1986) and Angelo (b. August 1997), all fathered by Ronald Chammah, who directed her in Milan noir (1987).
- She is, by far, the actress who has had the most films (16) in the Cannes's official competition, and one of the three who have won the Best Interpretation Awards twice - for Violette Nozière (1978) in 1978 and Pianiste, La (2001) in 2001 (the others are Helen Mirren for 'Cal' in 1984 and 'The Madness of King George' in 1995, and Barbara Hershey for "Shy People" in 1987 and "A World Apart" in 1988).
- Most nominated actress for the Cesar Award. She has been nominated 12 times, and won once, for _Cérémonie, La (1995/I)_ . (2004)
- Has recorded an album with French singer/"rock star" Jean-Louis Murat called "Madame Deshoulières". They sing/recite lyrics taken from poems of nearly unknown 16th century writer Antoinette Deshoulières. (Album released in France by "Labels" on 26 March 2001.)
- Plays the piano
- Isabelle Huppert starred with her daughter Lolita Chammah in three films, Vie moderne, La (2000), Malina (1991) and Une affaire de femmes (1988).
- During the shooting of the movie 8 femmes (2002), Isabelle was always hungry around 5 o'clock and had to eat the bread. This made Danielle Darrieux feel hungry too. So everyday at 5 o'clock, they would share a piece of bread together.
- Member of the jury at the Cannes Film Festival in 1984
- Graduated from the CNSAD (National Conservatory of Dramatic Art of Paris)
- Friend of Kim Cattrall
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