- Broke a bone in her wrist while filming Mary and Rhoda (2000) (TV)
- Her son, Richie, was born only 3 months earlier than her own 40-year-old mother's last child.
- Left dancing for acting because it "lacked the spotlight," and she "really wanted to be a star."
- First TV appearance was in 1955 as "Happy Hotpoint" the Hotpoint Appliance elf, in commercials aired during the "The Adventures of Ozzie & Harriet" (1952) TV show.
- Strong animal rights activist.
- Entered Betty Ford clinic for "Social Drinking Habit" 
- Son Richie's death in 1980 considered accidental, not suicide (hair trigger on gun went off - gun later removed from market for same reason)
- Celebrity sponsor of the Great American Meatout, March 20, 2001.
- Diagnosed with Type 1 Diabetes (insulin dependent) over 30 years ago.
- She recently testified before Congress (along with actors Kevin Kline and Jonathan Lipnicki and former astronaut Jim Lovell, commander of Apollo 13) calling for an increase in funding for diabetes research and support embryonic stem cell research, which she called "truly life affirming." Also present in the hearing room were about 200 children with diabetes and their families, who were in town for the Juvenile Diabetes Research Foundation International Children's Congress 2001. 
- Told David Letterman that her (and others') nickname for Dick Van Dyke when they did the "The Dick Van Dyke Show" (1961) together was Penis Von Lesbian, a play on his real name.
- Bronze statue capturing her character Mary's signature hat-toss went on display May 8, 2002 at the Minneapolis intersection where the scene for "Mary Tyler Moore" (1970) was originally filmed. On hand for the ceremony, Moore tossed her tam, but this time, into an appreciative downtown crowd.
- Founded MTM Enterprises in 1969 with ex-husband Grant Tinker. Sold the company in 1990.
- Appeared in the Broadway play "Sweet Sue" in 1988 with Lynn Redgrave and a fully nude Barry Tubb.
- Mary Tyler Moore portrayed the first Sam, who was in charge of the answering service on CBS Television's "Richard Diamond, Private Detective" (1957). Only her voice and her legs were known to the viewer.
- Measurements: 36-28-36 (in "Happy Hotpoint" ads as a young starlet), 36-24-36 (on "The Dick Van Dyke Show" (1961)), 36C/D-25-36 (after 1990 implants - removed in 1991) (Source: Celebrity Sleuth magazine)
- Walked out of the Neil Simon play "Rose's Dilemma" in December, 2003, citing problems with the playwright. Reportedly he sent her an insulting note prior to an appearance regarding her failure to memorize lines. The problem was that he had kept rewriting her lines and expected her to learn them on the spot. She was replaced by actress Patricia Hodges, but the play closed two months later to poor reviews.
- Was named as "Queen of Brooklyn" at the Welcome Back to Brooklyn Festival in 1996
- Was paired with Richard Chamberlain in 1967 for "Holly Golightly," a musical adaptation of Truman Capote's earlier novel (and film), Breakfast at Tiffany's (1961). When it became obvious during pre-Broadway tryouts that no amount of play-doctoring was going to save a potentially disasterous show, producer David Merrick announced that he was closing the show one week prior to it's scheduled Broadway opening, as he put it, "out of consideration for the audience."
- Was a heavy smoker during the time "The Dick Van Dyke Show" (1961) was in production. Has since quit. She was trying to quit smoking during filming directed by Carl Reiner when she discovered that she was going to be off-screen for the majority of the episode.
- She won Tony Awards in 1980 and in 1985. She won in 1980 after taking over the lead in the play "Whose Life Is It Anyway?". She was so good that she was given a special Tony because she was not eligible for a traditional nomination due to being a replacement performer. She won in 1985 when her company, MTM, backed the revival of the play "Joe Egg".
- MTM's mascot is a cute orange-striped kitten named Mimsie.
- Is, to the day, 2 years older than Jon Voight.
- The kitten that was the mascot for Mary's company, MTM Enterprises, would meow at the end of all MTM shows. In addition, it would even "wear costumes" reflecting the theme of the MTM show: At the end of each "St. Elsewhere" episode, the kitty is seen wearing a surgical mask and it had a policeman's hat tilted on its head at the end of "Hill Street Blues." and a detective's hat and pipe at the end of "Remmington Steele"
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