- Sister of actor Robert LuPone
- Awarded Tony for 'Evita'. 
- The name "Patti" is not shortened from or derived from Patricia, but rather from Ms. LuPone's mother's maiden name, which was "Patti".
- Ms. LuPone volunteered at the Craft and Folk Art Museum (CAFAM) in Los Angeles (1999-2000)
- Met husband Matt Johnston in 1986 when both were working on the TV movie LBJ: The Early Years (1987) (TV). They married two years later on the stage of New York City's Vivian Beaumont Theater at Lincoln Center while Patti was performing in "Anything Goes." Their son Joshua Luke Johnston was born on November 21, 1990.
- Is the first American actress to win an Olivier award in England for her performances in "Les Misérables" and "The Cradle Will Rock" in 1985
- In 1994 she had surgery to remove nodes from her vocal cords.
- She was a member of the very first class of the drama division at Juilliard. Other classmates included Kevin Kline (with whom she had an eight-year relationship in the 70s), David Ogden Stiers, and her future "Evita" co-star Mandy Patinkin.
- Performed as a teenager with her twin brothers William and Robert LuPone. They were billed as "The LuPone Trio."
- Is the cousin of 'Oz' creator Tom Fontana.
- Is a frequent collaborator with David Mamet.
- Won Broadway's 1980 Tony Award as Best Actress (Musical) for playing the title character, Eva Peron, in "Evita." She was also nominated as Best Actress (Featured Role - Musical) for "The Robber Bridegroom" in 1976 (a year that also saw her brother, Robert LuPone, earning a Tony nomination), and as Best Actress (Musical) for a revival of "Anything Goes" in 1988.
- Has recorded several solo discs including Patti LuPone Live!, Heatwave, Matters of the Heart, and the future release The Lady With a Torch. Patti can also be heard on other recordings such as Philadelphia Chickens, Grateful, Hey! Mr. Producer, Sondheim: A Celebration at Carnegie Hall, and The Family Guy Live in Vegas.
- Has one son, Joshua Luke Johnston, born November 21, 1990.
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