- Lower lip scar from being bitten by a dog as a child.
- Hosted concert in Central Park "Sheryl Crow and Friends". Guests included Keith Richards, Eric Clapton, Sarah McLachlan, Dixie Chicks and Chrissie Hynde. 
- Attended the University of Missouri.
- She was awarded an Honorary doctorate from the Southeast Missouri State University in Cape Girardeau, Missouri.
- Originally sang back-up for Michael Jackson and Don Henley.
- Her album "Come On Come On" was supposedly composed in the wake of a break-up with Owen Wilson.
- Graduated from the University of Missouri with a degree in music.
- Was a member of Sigma Alpha Iota, a women's music fraternity.
- Suffers from Sleep Paralysis
- Between 1994 and 2002, she has won nine Grammy Awards, including Best New Artist and Best Female Rock Vocalist.
- Ranked #44 on VH1's 100 Greatest Women of Rock N Roll
- Recorded an album in 1990 that was never released.
- Shares a birthday with actress Jennifer Aniston, actor Burt Reynolds, singer Kelly Rowland and Mike Shinoda of Linkin Park.
- She is a member of Kappa Alpha Theta sorority. She was initiated into the Alpha Mu chapter (Missouri).
- Best friend is Kelly Lynch
- Engaged to Lance Armstrong [September 5, 2005]
- Broke off engagement to Lance Armstrong [February 3, 2006].
- Underwent surgery for minimally invasive breast cancer [February 15, 2006].
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