- Gave birth to her first child, a daughter, Emerson Rose. [10 November 1997]
- #3 of Sci-Fi's Sexy 50, by Femme Fatales magazine. 
- Went to Fremont High School in Sunnyvale, California (class of '82).
- Attended De Anza College for 2 1/2 years and dropped out when she landed the part of a "The Love Boat" (1977) mermaid.
- Enjoys playing golf.
- The October 1996 issue of "Movieline" (US movie magazine) originally had a cover picture of her wearing nothing but rope wrapped around her. This proved too controversial and a second cover picture (her in a dress) was substituted.
- Was a San Franciso 49ers Cheerleader.
- Married actor Jon Tenney in New York City at FAO Schwarz. They spent their honeymoon night at the Four Seasons Hotel. [27 May 1994]
- Filed for divorce from Jon Tenney, citing irreconcilable differences. According to the petition submitted in Los Angeles Superior Court, the couple have agreed to joint custody of their five-year-old daughter, Emerson Rose. [28 February 2003]
- Measurements: 34B-23-34 (Source: Celebrity Sleuth magazine).
- Was Captain of the Fremont High School Featherettes Drill Team.
- In the mid-90s, a photo of her wrapped in nothing but a red Superman cape famously became the most downloaded image on America Online.
- Appeared in two completely different, unrelated productions in which she played a character who was targeted by assassination by a hit man played by Vincent Schiavelli: the television series "MacGyver" (1985) and Tomorrow Never Dies (1997).
- Screen-tested for the part of Jamie Buchman in "Mad About You" (1992), opposite Paul Reiser. Lost the part to Helen Hunt.
- First person to win the Screen Actors Guild Award for Outstanding Performance by a Female Actor in a Comedy Series for a show that has not yet completed it's first season.
- First husband Marcus Leithold said their marriage was over even before they got the wedding photos developed.
- Broke two ribs filming a scene for "Desperate Housewives" (2004) where she stumbles into a wedding cake
- Won two Awards at the British Glamour magazine's Women of the Year Awards in London, England on June 7, 2005. She was named US TV actress of the Year for her role as single mother Susan Mayer in "Desperate Housewives" (2004), and also got the Editor's Special Award for her talent to combine motherhood and a career while looking glamorous at the same time.
- Was named one of the 50 Most Beautiful People by People Magazine in 2005.
- Clairol has signed her to a multi-year contract to be the Nice 'n Easy haircolor spokesperson. She will promote the Brand across marketing vehicles, including television and print advertising, public relations, interactive, in-store and direct-to-consumer initiatives. [September 16, 2005]
- She and "Desperate Housewives" (2004) co-star Marcia Cross both made guest appearances on "Seinfeld" (1990) as prospective girlfriends of Jerry Seinfeld.
- Received the "World Actress Award" at the 2005 Women's World Awards in Leipzig, Germany.
- Her inspirational autobiography, "Burnt Toast: And Other Philosophies of Life" will be released on hardcover by publisher Hyperion on May 2, 2006 in the U.S.A. The audio CD version of the book narrated by Teri Hatcher will also be released on the same date. The book deals with a woman's struggle of to juggle life through good times and bad.
- Her heritage is Italian, Irish, and Native American.
- Claims that she was sexually molested by her then-uncle, Richard Hayes Stone, from age 5 to 9. [March 8, 2006]
- Suffered an injury to her right eye when a light bulb exploded on the "Desperate Housewives" (2004) set on April 25, 2006. Her cornea was scratched and she is wearing an eye patch, but she is expected to return to work in a few days.
- Named #7 in FHM's "100 Sexiest Women in the World 2005" special supplement. (2005)
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